Animal testing? Aberrant!!!

Schermata 2013-09-28 alle 12.20.29

Kladderadatsch 1933 (p. 569)

“Culture Day”
Text in the cartoon: “Vivisection Forbidden”
Down: “Heil Goering (Nazi salute)”

Schermata 2013-09-28 alle 12.13.04

 

Kladderadatsch 1933 (p. 579)
“The Nightmare of the vivisectors”

 

 
In former times, it was possible to do without “animal testing”, but at what price?

Physicist Erwin Schrödinger’s Google doodle marks quantum mechanics work

Google’s latest doodle marks the birthday of Erwin Schrödinger, the Nobel prize-winning quantum physicist whose eponymous equation lies at the heart of quantum mechanics.

Born in Vienna in 1887 to a factory owner and his Austrian-English wife, Schrödinger was tutored at home as a child and went on to study theoretical physics at the University of Vienna before undertaking voluntary military service, later returning to academia to study experimental physics.

Renewed military service during the first world war broke up his studies before he was sent back to Vienna in 1917 to teach a course in meteorology.

However, it was not until his late 30s that he was to change forever the face of physics by producing a series of papers that were all written and published over the course of a six-month period of theoretical research.

By 1925, then a professor of physics at the University of Zurich and holidaying in the Alps, Schrödinger formulated a wave-equation that accurately gave the energy levels of atoms. It formed the basis of the work that would earn him the Nobel prize in physics in 1933.

In subsequent years, he repeatedly criticised conventional interpretations of quantum mechanics by using the paradox of what would become known as Schrödinger’s cat. This thought experiment was designed to illustrate what he saw as the problems surrounding application of the conventional, so-called “Copenhagen interpretation” of quantum mechanics to everyday objects.

Other work focused on different fields of physics, including statistical mechanics, thermodynamics and colour theory. In a celebrated 1944 book, What Is Life?, he turned to the problems of genetics, taking a close look at the phenomenon of life from the point of view of physics.

He died in Vienna in January 1961 from the tuberculosis that had affected him throughout his life and was buried in the western Austrian village of Alpbach.

(from The Guardian.com)

Bacteriophage phiX174

In 2000, the Protein Data Bank, include in its database, the structure of Bacteriophage phix174, with an article like a: dedicandovi un articolo come “Stucture of the Month”.

A bacteriophage is a virus that attacks bacteria. The phiX174 bacteriophage attacks the common human bacteria Escherichia coli, infecting the cell and forcing it to make new viruses. Do you think that viruses are living organisms? PhiX174 is composed of a single circle of DNA surrounded by a shell of proteins. That’s all. It can inject its DNA into a bacterial cell, then force the cell to create many new viruses. These viruses then burst out of the cell, and go on to hijack more bacteria. By itself, it is like an inert rock. But given the proper bacterial host, it is a powerful reproducing machine.
What do you think? Is it alive?

Read More Bacteriophage phix174 Molecule Of the Month PDB 2000

Chimera – Installation and demo

Ecco una guida rapida e semplice per installare Chimera, un ottimo software molto semplice da utilizzare, per eseguire visualizzazioni (2d e 3d) e semplici calcoli, su molecole organiche / inorganiche e sistemi macromolecolari (come proteine, DNA, RNA etc).

images (4)

Per iniziare potete scaricare da qui:
http://www.cgl.ucsf.edu/chimera/download.html
(questo programma è stato sviluppato dalla University of California )

Per chi non conoscesse l’architettura del proprio pc windows (32 o 64 bit) può dare un’occhiata su questo sito:
http://it.kioskea.net/faq/1147-32-o-64-bit-come-faccio-a-saperlo

Una volta che clicchiamo sul download si aprirà la licenza, date una lettura, scorrete in basso e cliccate su “Accept”.
(il software non installa malware / virus/ bot o spyware).
Alla fine del download, cliccando sull’icona del file, facciamo partire l’eseguibile e l’installazione del programma…
In pochi minuti sarà installato (ricordatevi di selezionare “Precompile python libraries” alla fine della installazione).

Per utilizzare il programma basterà cliccare sull’icona Chimera 1.8 e si avvierà il software.
Ecco la schermata iniziale:

chimera

Cliccando su File, poi Fetch ID, si aprirà un piccolo riquadro, dove sulla destra potremo scrivere l’entry id della struttura del pdb di esempio… 1yti
Premiamo su Fetch e si aprirà la struttura nella finestra del software!
Cliccate su Presets in alto e scegliete uno dei diversi modi di visualizzazioni in modo da evidenziare solo alcuni particolari della struttura o evidenziarli in maniera differente.

Schermata 2013-07-25 alle 09.44.42

Buon Divertimento!

A mice will save your life!

La tecnologia degli anticorpi monoclonali si è sviluppata negli anni ’70, quando Kohler e Milstein riuscirono a creare ibridi con caratteristiche tumorali (perdita inibizione da contatto) e capace di produrre anticorpi.
Queste cellule, dette ibridomi, rappresentavano dunque una inesauribile fonte di anticorpi monospecifici (monoclonali).

Come avviene la produzione degli anticorpi monoclonali?

1057796_485790118181568_100375591_n
Continua la lettura dal Nostro Wiki!

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